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Prescribing information for zyprexa

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Common side effects of Zyprexa include: lack of energy, dry mouth, increased appetite, sleepiness, tremor shakes having hard or infrequent stools, dizziness, changes in behavior, or restlessness. What other drugs will affect olanzapine Zyprexa, Zyprexa Zydis? The rate of discontinuation due to adverse reactions was significantly greater with oral olanzapine than placebo 13% vs 7%. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. mebeverine

Common side effects of zyprexa

Be sure that your hands are dry. Zyprexa Relprevv is intended for deep intramuscular gluteal injection only and should not be administered intravenously or subcutaneously. Problems with control of body temperature: You could become very hot, for instance when you exercise a lot or stay in an area that is very hot. It is important for you to drink water to avoid dehydration. In all studies, the effectiveness of Zyprexa was assessed using various symptom-rating scales. What benefit has Zyprexa shown during the studies?

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Olanzapine clearance is about 40% higher in smokers than in nonsmokers, although dosage modifications are not routinely recommended. The vial should be agitated immediately prior to product withdrawal. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine.

Medline Plus 2013 Olanzapine

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Olanzapine belongs to a class of drugs called atypical antipsychotics. If any of these effects persist or worsen, notify your doctor or promptly.

Zyprexa can be taken with or without food

Some patients have experienced weight gain while using Zyprexa Intramuscular. You may need to have regular weight checks while you use Zyprexa Intramuscular. Transient, asymptomatic elevations of hepatic transaminases were commonly seen, especially early in treatment. Olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using olanzapine. ECG parameters, including QT, QTc, and PR intervals. These reactions were correlated with an unintentional rapid increase in serum olanzapine concentrations to supra-therapeutic ranges in some cases. While a rapid and greater than expected increase in serum olanzapine concentration has been observed in some patients with these reactions, the exact mechanism by which the drug was unintentionally introduced into the blood stream is not known. Clinical signs and symptoms included dizziness, confusion, disorientation, slurred speech, altered gait, difficulty ambulating, weakness, agitation, extrapyramidal symptoms, hypertension, convulsion, and reduced level of consciousness ranging from mild sedation to coma. Time after injection to event ranged from soon after injection to greater than 3 hours after injection. The majority of patients were hospitalized and some required supportive care, including intubation, in several cases. All patients had largely recovered by 72 hours. What should I do if I miss a dose? If the medication releases too quickly, your drug levels may be too high. Precautions noted below need to be carefully weighed. When using ZYPREXA and fluoxetine in combination, also refer to the Clinical Studies section of the package insert for Symbyax. The term somnolence was combined under sedation.

Zyprexa ingredients

The possibility of a suicide attempt is inherent in schizophrenia, and close supervision of high-risk patients should accompany drug therapy. Olanzapine can cause high blood sugar hyperglycemia. If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine. Khan, I. A. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat. An injection of a larger dose produces a dose-proportional increase in the systemic exposure. The olanzapine exposure after doses of Zyprexa Relprevv corresponds to exposure for oral doses of olanzapine. Because olanzapine is highly metabolized before excretion and only 7% of the drug is excreted unchanged, renal dysfunction alone is unlikely to have a major impact on the pharmacokinetics of olanzapine. The pharmacokinetic characteristics of olanzapine were similar in patients with severe renal impairment and normal subjects, indicating that dosage adjustment based upon the degree of renal impairment is not required. In addition, olanzapine is not removed by dialysis. The effect of renal impairment on metabolite elimination has not been studied. The terms alanine aminotransferase ALT aspartate aminotransferase AST and hepatic enzyme were combined under liver enzymes. How should I store Zyprexa? ALT, AST, and GGT. Please read the Hypodermic Needle-Pro Instructions for Use before proceeding with Step 3. Failure to follow these instructions may result in a needlestick injury. Japanese, Chinese and Caucasians, especially after normalization for body weight differences. Dosage modifications for race are, therefore, not recommended. Loosen the powder by lightly tapping the vial. For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc Fridericia corrected and PR intervals. Safety and efficacy of Zyprexa and fluoxetine in combination was determined in clinical trials supporting approval of Symbyax fixed dose combination of Zyprexa and fluoxetine. Zyprexa Intramuscular is to be used only by the patient for whom it is prescribed. Do not share it with other people. aromasin

Smiths Medical ASD, Inc

Hypodermic Needle-Pro needle with needle protection device. For obese patients, a 2-inch 50 mm 19-gauge or larger needle not included in convenience kit may be used. To help prevent clogging, a 19-gauge or larger needle must be used. Attach the new safety needle to the syringe prior to injection. Once the suspension has been removed from the vial, it should be injected immediately. For deep intramuscular gluteal injection only. Do not inject intravenously or subcutaneously. Select and prepare a site for injection in the gluteal area. After insertion of the needle into the muscle, aspirate for several seconds to ensure that no blood appears. If any blood is drawn into the syringe, discard the syringe and the dose and begin with a new convenience kit. The injection should be performed with steady, continuous pressure. Do not massage the injection site. Engage the needle safety device. Dispose of the vials, needles, and syringe appropriately after injection. The vial is for single-use only. The data in each column represent data for those patients who completed treatment periods of the durations specified. Little clinical trial data is available on weight gain in adolescents with olanzapine beyond 6 months of treatment. Visually confirm that the needle is fully engaged into the needle protection sheath. Open the prepackaged Hypodermic Needle-Pro syringe and needle with needle protection device. If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Contact your doctor right away if you think you may be dehydrated. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, since steady state for olanzapine would not be achieved for approximately 1 week in the typical patient. If you have diabetes, follow your doctor's instructions about how often to check your blood sugar while taking Zyprexa. casodex

Zyprexa may not be right for you

Do not use with Paraldehyde. These trials included patients with or without psychotic features and with or without a rapid-cycling course. Store at room temperature away from moisture, heat, and light. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyprexa Intramuscular while you are pregnant. Using Zyprexa Intramuscular during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Zyprexa Intramuscular is found in breast milk. Do not breast-feed while using Zyprexa Intramuscular. The rate of discontinuation due to adverse reactions was greater with olanzapine than placebo 13% vs 7%. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. price of generic adalat without insurance

Zyprexa drug interactions

Increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality dementia-related psychosis. Zyprexa is not approved for treating psychosis in elderly people with dementia. What should I avoid while taking Zyprexa? Multiple doses of olanzapine did not affect the pharmacokinetics of theophylline or its metabolites. The fundamental pharmacokinetic properties of olanzapine are similar for Zyprexa Relprevv and orally administered olanzapine. Refer to the section below describing the pharmacokinetics of orally administered olanzapine for details. There was a statistically significant difference between Zyprexa Relprevv and oral olanzapine in potentially clinically significant changes for high leukocyte count 0% Zyprexa Relprevv vs 1% oral olanzapine. May cause side effects to become worse. Zyprexa is indicated as an integral part of a total treatment program for pediatric patients with schizophrenia and bipolar disorder that may include other measures psychological, educational, social for patients with the disorder. Effectiveness and safety of Zyprexa have not been established in pediatric patients less than 13 years of age. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The switch from oral olanzapine to Zyprexa Relprevv changes the pharmacokinetics from an elimination-rate-controlled to an absorption-rate-controlled process. The switch to Zyprexa Relprevv may require treatment for a period of approximately 3 months to re-establish steady-state conditions. This information should not be used to decide whether or not to take Zyprexa Intramuscular or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zyprexa Intramuscular. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zyprexa Intramuscular. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zyprexa Intramuscular. Post-injection Delirium Sedation Syndrome PDSS. PDSS is a serious problem that can happen after you get a Zyprexa Relprevv injection if the medicine gets in your blood too fast. The following adverse reactions have been identified during post-approval use of Zyprexa. Because these reactions are reported voluntarily from a population of uncertain size, it is difficult to reliably estimate their frequency or evaluate a causal relationship to drug exposure. Keep Zyprexa away from light. neurontin

General information about zyprexa

Patients with the following MedDRA terms were counted in this category: hypersomnia, lethargy, sedation, somnolence. Examination of population subsets race and gender did not reveal any differential responsiveness on the basis of these subgroupings. Overall, there was no difference in the incidence of discontinuation due to adverse reactions 2% for oral olanzapine vs 2% for placebo. Constipation; dizziness; drowsiness; dry mouth; light-headedness; pain, redness, or swelling at the injection site; weakness; weight gain. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Medline Plus. 2013. Olanzapine. The possibility of multiple drug involvement should be considered. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. Gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered. Olanzapine is a yellow crystalline solid, which is practically insoluble in water. Patients should be counseled that dyslipidemia has occurred during treatment with Zyprexa. But now don't care as much when I go places. I noticed I am more calm and positive. This medicine makes me want to be more productive and happy. I am on my 2nd-3rd week of taking it. I don't have any side effects so far. The information contained in the Truven Health Micromedex products as delivered by Drugs.

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Smiths Medical ASD, Inc. Fluvoxamine, a CYP1A2 inhibitor, decreases the clearance of olanzapine. This results in a mean increase in olanzapine Cmax following fluvoxamine of 54% in female nonsmokers and 77% in male smokers. The mean increase in olanzapine AUC is 52% and 108%, respectively. Lower doses of olanzapine should be considered in patients receiving concomitant treatment with fluvoxamine. Both metabolites lack pharmacological activity at the concentrations observed. Patients with the following COSTART terms were counted in this category: akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, masked facies, tremor. The magnitude of the impact of this factor is small in comparison to the overall variability between individuals, and therefore dose modification is not routinely recommended. When using Zyprexa and fluoxetine in combination, also refer to the Drug Interactions section of the package insert for Symbyax. The effect of olanzapine on labor and delivery in humans is unknown. Parturition in rats was not affected by olanzapine. Decreased blood pressure when you change positions, with symptoms of dizziness, fast or slow heartbeat, or fainting. However, the efficacy of repeated doses of intramuscular olanzapine for injection in agitated patients has not been systematically evaluated in controlled clinical trials. Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemia, dyslipidemia, and weight gain. Tell your doctor if your condition persists or worsens. Olanzapine Monotherapy in Adults: An assessment of the premarketing experience for oral olanzapine revealed an association with asymptomatic increases in ALT, AST, and GGT. Undesirable alterations in lipids have been observed with olanzapine use. The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Zyprexa is used to treat adults with schizophrenia. Schizophrenia is a mental illness that has a number of symptoms, including disorganised thinking and speech, hallucinations hearing or seeing things that are not there suspiciousness and delusions mistaken beliefs. Zyprexa is also effective in maintaining improvement in patients who have responded to an initial course of treatment. ECG. Vital signs were usually within normal limits following overdoses. cheap skelaxin vs

Zyprexa adult dosage

In an oral olanzapine study in lactating, healthy women, olanzapine was excreted in breast milk. Olanzapine has not been systematically studied in humans for its potential for abuse, tolerance, or physical dependence. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Patients and caregivers should be counseled that a potentially fatal symptom complex sometimes referred to as NMS has been reported in association with administration of antipsychotic drugs, including Zyprexa. Takeshita K, Saisho Y, Kitamura K, et al. Pneumonitis induced by ou-gon scullcap. The resulting solution should appear clear and yellow. Zyprexa IntraMuscular reconstituted with Sterile Water for Injection should be used immediately within 1 hour after reconstitution. Discard any unused portion. Shake the vial vigorously until the suspension appears smooth and is consistent in color and texture. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS has been reported with olanzapine exposure. Olanzapine did not influence the pharmacokinetics of diazepam or its active metabolite N-desmethyldiazepam. Increased incidence of stroke or “mini-strokes” called transient ischemic attacks TIAs in elderly people with dementia-related psychosis elderly people who have lost touch with reality due to confusion and memory loss. Zyprexa is not approved for these patients. Zyprexa Relprevv is a powder for suspension for intramuscular use only. Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you use Zyprexa Intramuscular. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. HCl is a fixed-dose combination of ZYPREXA and fluoxetine. For specific information about overdosage with lithium or valproate, refer to the Overdosage section of the package inserts for these products. For specific information about overdosage with olanzapine and fluoxetine in combination, refer to the Overdosage section of the Symbyax package insert. bupropion will it be availability

How should i store zyprexa

Zyprexa is also used to treat moderate to severe manic episodes extremely high mood in adults. It can also be used to prevent the recurrence of these episodes when symptoms come back in adults with bipolar disorder a mental illness with alternating periods of high mood and depression who have responded to an initial course of treatment. Attach a new safety needle to the syringe. Caution should be exercised in patients with signs and symptoms of hepatic impairment, in patients with pre-existing conditions associated with limited hepatic functional reserve, and in patients who are being treated with potentially hepatotoxic drugs. The symptoms of schizophrenia may include thoughts of suicide or of hurting yourself or others. If you have these thoughts at any time, tell your doctor or go to an emergency room right away. When indicated, dose escalation should be performed with caution in these patients. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. This medicine may increase your weight. Your doctor may need to check your or your child's weight on a regular basis while you are using this medicine. cheapest generic grifulvin

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What are the possible side effects of zyprexa

Zyprexa brand names

Zyprexa should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Our Zyprexa Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Olanzapine's specific metabolic profile is presented below. is topamax in us

Zyprexa dosing information

The stated frequencies of adverse reactions represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse reaction of the type listed. A reaction was considered treatment emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation. Reactions listed elsewhere in labeling may not be repeated below. The entire label should be read to gain a complete understanding of the safety profile of Zyprexa Relprevv. NMS has been reported in association with administration of antipsychotic drugs, including olanzapine. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia. Additional signs may include elevated creatinine phosphokinase, myoglobinuria rhabdomyolysis and acute renal failure. order cheap metoprolol shopping uk

Does zyprexa interact with other medications

It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Y-MRS total score. In an identically designed trial conducted simultaneously with the first trial, olanzapine demonstrated a similar treatment difference, but possibly due to sample size and site variability, was not shown to be superior to placebo on this outcome.

Zyprexa forms and strengths

In a study in lactating, healthy women, olanzapine was excreted in breast milk. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. This medicine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down.

What is the most important information I should know about Zyprexa Relprevv? Bent or damaged needles can result in breakage or damage to the tissue or accidental needle puncture. What should I avoid while receiving Zyprexa Relprevv? The symptoms of schizophrenia include hearing voices, seeing things that are not there, having beliefs that are not true, and being suspicious or withdrawn. Increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality dementia-related psychosis. feldene

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